Dr. Wei Zhang
Associate Professor, Chemistry

Education:

B.S., Nanjing University
Ph.D., University of Pittsburgh
Postdoc, University of Pittsburgh

Current Position:
Associate Professor, Chemistry
Office: S-1-127
Telephone: 617-287-6147
EMail: wei2.zhang@umb.edu

Group website

Teaching Interests:

Organic chemistry, green chemistry, medicinal chemistry, and general chemistry

Research Interests:

Organic, Medicinal, and Green Chemistry including fluorous technology, diversity-oriented synthesis, microwave-assisted synthesis, multicomponent reactions, parallel and high-throughput synthesis, preparation of drug-like compounds and natural product analogs, organocatalysis, and free radical synthesis.

Selected Publications:

• Zhang, W. “Fluorous Linker-Facilitated Chemical Synthesis” Chem. Rev. 2009, 109, in press.
• Zhang, W.; Cai, C. “New Chemical and Biological Applications of Fluorous Technologies” Chem. Commun. Feature article, 2008, 5686-5694.
• Zhang, W. “Fluorinated Stationary Phases for HPLC Applications” J. Fluorine Chem. 2008, 129, 910-919.
• Zhang, W. “Fluorous-Enhanced Multicomponent Reactions for Making Drug-Like Library Scaffolds” Comb. Chem. High Throughput Screening 2007, 10. 219-229.
• Zhang, W.; Curran, D. P. “Synthetic Applications of Fluorous Solid-phase Extraction (F-SPE)” Tetrahedron Report No. 777, Tetrahedron 2006, 62, 11837–11865.
• Zhang, W.; Lu, Y.; Chen, Chen, C. H.-T. “Fluorous Mixture Synthesis of Two Libraries with Novel Hydantoin- and Benzodiazepinedione-Fused Heterocyclic Scaffolds” J. Comb. Chem. 2006, 8, 687-695.
• Zhang, W.; Lu, Y.; Geib, S.  “Synthesis of Fluorous and Non-Fluorous Polycyclic Systems by One-Pot, Double Intramolecular 1,3-Dipolar Cycloaddition of Azomethine Ylides” Org. Lett. 2005, 7, 2269-2272.
• Zhang W. “Fluorous Tagging Strategy for Solution-Phase Synthesis of Small Molecules, Peptides and Oligosaccharides” Curr. Opin. Drug Discovery Dev. 2004, 7, 784-797.  
• Zhang, W. “Fluorous Synthesis of Heterocyclic Systems” Chem. Rev. 2004, 104, 2531-2556.
• Zhang, W. “Fluorous Technologies for Solution-Phase High-Throughput Organic Synthesis” Tetrahedron Report No.640, Tetrahedron 2003, 59, 4475-4489.
• Zhang, W.; Luo, Z.; Chen, H.-T.; Curran, D. P. “Solution-Phase Preparation of A 560-Compound Library of Individually Pure Mappicine Analogs by Fluorous Mixture Synthesis” J. Am. Chem. Soc. 2002, 124, 10443-10450.